CELL-BASED AND READY-TO-USE CONCEPT FOR IN VITRO INTESTINAL ABSORPTION EVALUATION

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Average of Papp values of different reference compounds (n=13 independent batches).

Introduction

>CacoReady™ is an innovative cell-based and ready-to-use kit. The kit consits of 24 and 96-transwell permeable supports seeded with differentated and polarized Caco-2 barriers on polycarbone microporous filters. CacoReady™ allows in vitro intestinal absorption evaluation of drug targets. CacoReady™ is flexibile since plates can be used up to 5 days after ideal cell barrier differentiation at day 21. CacoReady™ is time and cost-saving tool for early stage drug discovery and development

>> Flyer CacoReady™ (PDF)

CacoReady™ Benefits

• Provides 21-day cell barriers allowing reduction of in-house maintenance and handling of Caco-2 cell cultures
• High flexibility as kit is useable up to 5 days after 21-day cell barrier differentiation
• High reproducibility
• Time saving and cost-effective
• Adaptable to automated procedures and High Throughput Screening
• Easy and clean handling
• Full cell functionality after transportation
• Shipping medium easy to remove by liquefaction at 37 ºC

CacoReady™ Features

• Cell-based
• Ready-to-use
• 24 and 96-HTS insert-integrated plate formats
• Exclusive solid shipping medium